More about Type 1 Diabetes and pathogenic MSRV

Type 1 Diabetes (T1D) is a chronic disease that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. As a result, the pancreas produces little or no insulin, a hormone needed to allow sugar (glucose) to enter cells and produce energy. There is no cure today for T1D, but insulin replacement therapy for life allows patients to manage the condition. Yet, even with careful management, long-term complications generally develop over decades as a result of fluctuations in blood sugar levels. Serious long-term complications include heart disease, stroke, kidney failure, foot ulcers and damage to the eyes.  GeNeuro has shown MSRV-ENV protein expression in the pancreas of human T1D patients using immunohistochemistry. It also demonstrated that exogenous application of recombinant MSRV-ENV protein causes dysregulation of the response of rat insulinoma cells to glucose and that direct injection into NOD-SCID mice leads to hyperglycaemia and insulitis similar to human T1D. It has also shown that the effects of MSRV-ENV can be blocked in vitro and in vivo with GNbAC1. These experiments have established the presence of the protein in human disease and shown in model systems that MSRV-ENV can replicate features of human disease.